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KMID : 0829220170410040155
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Korean Journal of Oral and Maxillofacial Pathology
2017 Volume.41 No. 4 p.155 ~ p.162
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Increased Expression of CTGF in Periodontitis Tissue and Its Role for Enhanced Mature Osteoclast Survival
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Han Hye-Yeon
Park Jong-Cheol
Ryu Mi-Heon
Bae Moon-Kyung
Kim Hyung-Joon
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Abstract
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Connective tissue growth factor (CTGF, CCN2) is one of the multi-functional secreted proteins which belong to CCN family of cysteine-rich growth factors. CTGF is known to have pivotal roles in embryonic endochondral ossification but its role in relevance to periodontitis is never been determined. To identify new molecular mediators associated with periodontitis-induced bone resorption, we have analyzed publicly available GEO database and found the markedly augmented CTGF mRNA expression in periodontitis gingival tissues. The existence of CTGF significantly enhanced mature osteoclasts survival which accompanied by reduction in TUNEL-positive nuclei and PARP cleavage. These results may provide another line of evidence the CTGF mediated prolonged osteoclast survival and subsequent increased bone resorption in the periodontitis patients.
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KEYWORD
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Periodontitis, CTGF, Osteoclast, Bone resorption
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